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Death in patients with pulmonary hypertension is most often a result of right ventricular failure, but mechanisms for progression from RV hypertrophy to failure are poorly understood.
Our findings therefore suggest that the mechanisms for progression to severe mitochondrial dysfunction in type 2 diabetes are contributed by NO-dependent mechanisms.
The senescence studies also suggested mechanisms for progression to melanoma.
Prostate cancer is an extremely heterogeneous disease; the underlying mechanisms for progression to CRPC are complex [ 138, 159].
Ethical approval for the use of Cambridge samples and data collection was granted by the local Research Ethics Committee under ProMPT (Prostate Mechanisms for Progression and Treatment) "Diagnosis, investigation and treatment of prostate disease" (MREC 01/4/061).
Ethical approval for the use of samples and data collection was granted by the local Research Ethics Committee under ProMPT (Prostate Mechanisms for Progression and Treatment) "Diagnosis, investigation and treatment of prostate disease" (MREC 01/4/061).
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Many tumour cells have been reported to have mutations in the p53 tumour-suppressive gene and it is frequently one possible mechanism for progression of tumours.
Moreover, vitamin D deficiency could contribute to an inappropriately activated or unsuppressed RAS, as a mechanism for progression of CKD and/or cardiovascular disease.
Studies have -suggested cross-linking of collagen fibres and the accumulation of aggregated glycation end--products (AGEs) as a potential mechanism for progression- of osteoarthritis by ageing.
This study establishes a contributing mechanism for progression of prostate cancer cells to a more apoptosis-resistant and thus malignant phenotype, whereby increased expression of RUNX2 modulates the expression of apoptosis-associated factors, specifically Bcl-2.
The encoded protein by C8orf4 gene may play a role in the NF- κB and ERK1/2 signaling pathways, highlighting inflammation as a possible pathogenesis mechanism for progression in PD [ 81].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com