Sentence examples for mechanisms for activating from inspiring English sources
The best-studied mechanisms for activating mTORC1 and protein synthesis are via receptor tyrosine kinase activation by growth factors such as insulin-like growth factor (IGF -I and IGF -In (36) and nutrinsulin activation by branched-chain amino acids (36).
Clearly, the wide diversity of sigma factors and transcriptional regulators in C. metallidurans CH34 points to intricate regulatory mechanisms for activating genes in response to environmental stimuli.
This suggests that there might be alternative mechanisms for activating soxS expression in the conditions tested (which were different from conditions used for the micoarray experiment).
Knowledge of the genetic abnormalities present in pediatric LGAs is limited, though recent studies have identified BRAF translocations, chromosomal duplications, and occasional base mutations in low-grade astrocytomas[18], [25], as well as diverse mechanisms for activating the ERK/MAPK pathway in pilocytic astrocytomas [23].
Indeed, intact talin binds vinculin with low affinity (Patel et al, 2006); the mechanisms for activating the vinculin-binding sites in the talin rod remain to be determined.
However, our work shows that other mechanisms for activating Erk, including via oncogenic Ras mutations in lung cancer cells or via serum factors in osteosarcoma cells also lead to Eps8-dependent bleb-based migration.
TTS toxins use a unique mechanism for activating their enzymatic activities.
Furthermore, it has also been suggested that Rho GTPases are regulated by a fine balance between GEF and GAP activities, and that the inactivation of GAP activity is a physiologically important regulatory mechanism for activating Rho GTPases [ 19].
These domains interact when the enzyme is in the inactive conformation, and the V600E mutation shifts the kinase into the active conformation, suggesting that disrupting this interaction is a primary mechanism for activating the BRAF oncogenes.
Phosphorylation is a common mechanism for activating proteins within signaling pathways.
An activating mutation at codon 600 converting valine to glutamic acid (V600E), is another mechanism for activating BRAF without upstream RAS phosphorylation in LGG.
