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Finally, the differential effects of the various organophosphates raise the intriguing possibility that safer compounds could be engineered that avoid the critical mechanisms evoking developmental neurotoxicity.
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Our results thus point to the potential for PFAAs to evoke developmental neurotoxicity through direct actions on replicating and differentiating neurons, effects distinct from the indirect consequences of endocrine disruption or metabolic or other secondary mechanisms.
The molecular mechanisms evoked in response to statins or docetaxel have been investigated in cell culture and animal models.
This report is the first to describe the apoptotic mechanism evoked by targeting the β-tubulin CCT- β-tubulin CCT-
For over half a century, the field of developmental biology has leveraged computation to explore mechanisms of developmental processes.
In particular, Dr. Faustman is interested in the molecular and cellular mechanisms of developmental and reproductive toxicants, characterizing in vitro techniques for developmental toxicology assessment, and development of biologically based dose-response models for non-cancer risk assessment.
Mechanisms underlying the developmental origins of disease.
Duncan found that courts looked for remorse in "psychologically naïve ways, without regard for defense mechanisms, developmental stages, or the ambiguity that inheres in human behavior".
This initiates signaling which, by unknown mechanisms, regulates vertebrate developmental processes.
Hoogenkamp, M. et al. The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.
However, the mechanisms underlying this developmental difference are unknown.
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