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The ability of a large number of protein structural motifs to catalyze relevant chemical reactions has played a significant role in the elaboration of repair mechanisms during evolution.
This redundancy may have supported the diversification of transcriptional mechanisms during evolution and the development of increasing organismal complexity [4].
From biological evolution point of view, it is likely that this nested structure stems from a simple core and is later wrapped with complex regulation mechanisms during evolution.
This reflects an early development of cell-type-specific signaling mechanisms during evolution to ensure the development as well as the maintenance of cellular differentiation.
The increasing complexity of regulatory mechanisms during evolution is aided by the appearance of splice variation, as it provides a greater variety of protein species independently of gene number [3].
Interestingly, many microbial pathogens including C. jejuni have adapted mechanisms during evolution to exploit TJs, AJs, FAs and/or HDs in infected cells in order to proliferate, survive and sometimes persist within the host [ 12, 19- 21].
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Formation of one such mechanism during evolution apparently was enough for most plant species.
As previous works pointed out [ 66, 87, 111] the development of advanced jaw closure mechanisms during turtle evolution likely required a more rigid skull that is compliant with higher bite performance and the loss of the basipterygoid process in association with the formation of an advanced trochlear system is therefore consistent with this pattern.
To regulate plant development and deal with environmental stress, plants have acquired complex mechanisms during their evolution to sense and transmit environmental stimuli.
The conservation of these mechanisms during vertebrate evolution further emphasizes the important contribution of the somatic compartment to oocyte developmental competence acquisition during oogenesis and paves the way for future investigations aiming at better understanding what makes a good egg.
Phylogenetic analysis indicated that sRNA pathways were very ancient regulatory mechanisms during the evolution of land plants, and most homologous genes, such as DCLs, AGOs and RDRs, had already diverged in the primitive vascular plants.
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