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More generally, the role of IDO and KP activity in stem cell biology and the exact nature of underlying mechanisms controlling stem cell proliferation and differentiation are completely unknown.
However, before that, clear elucidation of basic molecular mechanisms controlling stem cell biology is of importance.
Whereas the molecular players underlying stem cell niche organization diverge between plants and animals, other mechanisms controlling stem cell activity seem to be conserved even between the kingdoms of life.
In line with this, common regulatory mechanisms controlling stem cell activities in a wide range of model organisms as well as among different stem cell niches within the same organism begin to emerge (Heidstra and Sabatini, 2014; Lodha et al., 2009; Simons and Clevers, 2011).
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Following the detailed description of the molecular mechanisms controlling plant stem cell pluripotency, one might wonder about the relevance of such an elaborate system for plant survival.
Our findings reveal that while a diversity of changes are caused by the aging process, the mechanisms controlling muscle stem cell responses and their age-specific alternations are evolutionarily conserved between humans and mice.
ULT1 function thus represents a novel chromatin-mediated mechanism that activates genes controlling stem cell fate in plants.
These synthetic matrices, which comprise of "off-the-shelf" components and are easy to synthesize, provide an ideal tool to elucidate the molecular mechanisms that control stem cell fate.
DOI: http://dx.doi.org/10.7554/eLife.01857.002 In adult life, many organs rely on stem cells to maintain their integrity by replenishing lost cells during tissue homeostasis and regeneration, yet the regulatory mechanisms that control stem cell proliferation, self-renewal, and differentiation are still not fully understood.
Understanding the roles and mechanism of action of niches in controlling stem cell behavior is critical for growing and expanding stem cells in vitro, while maintaining stem cell characteristics and the full array of differentiation potential: an essential first step in the use of stem cells in regenerative medicine.
Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation.
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