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In order to examine mechanisms controlling endothelial function, we propose to examine alterations in genetic expression profiles in the endothelium in situ following decompression, using rats or mice as experimental models.
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This indicates that distinct mechanisms control endothelial cell attachment at different sites and may explain the distinct requirement of correct N-glycosylation of Treg for homing to the ALN but the not MLN.
In summary, Carmeliet and colleagues made an important advance by identifying a new mechanism controlling endothelial sprouting and angiogenesis.
Apoptosis is an important mechanism that controls endothelial cell number and regeneration.
We report here a mechanism to control endothelial sprouting in 3D collagen matrices, which mimics activation of the angiogenic switch.
A variety of risk factors contributes to dysfunction of endothelial cells through changes in eNOS expression and activity [ 113– 116]: Both transcriptional and post-transcriptional mechanisms controlling eNOS mRNA levels have been associated with the same [ 117– 117].
In order to understand the mechanisms controlling blood flow at different levels of the microvascular network, detailed investigation is needed of the mechanisms of interplay between endothelial cell Ca2+ signalling, responsible for production of vasodilator agents, with Ca2+ signalling and contractility of myocytes and pericytes induced by different vasoconstrictors.
Rac1 has been shown to control endothelial permeability [ 35, 36].
Control endothelial cells were maintained under normoxia.
VE-cadherin internalization appears to be a key mechanism that controls the overall organization of endothelial monolayers in vitro and vascular organization in vivo[ 9, 14- 19].
Understanding endothelial cell (EC) differentiation is a step forward in tissue engineering, controlling angiogenesis, and endothelial dysfunction.
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