Sentence examples for mechanisms centered from inspiring English sources

In this study, we show that ubiquitylation and degradation of Rpb1 encompasses an unusually wide variety of ubiquitin-related mechanisms centered on the Def1 protein.

Patients with transcription factor MODY respond better to sulfonylureas than to metformin [ 16], illustrating the pathophysiological mechanisms centered in the β cell (where insulin secretagogues such as sulfonylureas act) for this form of the disease.

Exquisite control of this actin-sensing mechanism centered on 5q candidate tumor-suppressor genes would be critical to controlling the proliferation and proper migration of hematopoietic progenitors and stem cells.

In my Ph.D. research I, used muscle stem cells as a model system for studying the gene regulation mechanism centered on a master transcription factor called Pax7.

Our findings provide new insights unveiling a mechanism centered on phosphorylation-dependent prolyl-isomerization by Pin1 as responsible for sustained Notch signaling in breast cancer cells, regardless of Fbxw7α status.

The prominent presence in the signature of INHBA in all cancers strongly suggests a biological mechanism centered on activin A induced TGF-β signaling, because activin A is a member of the TGF-β superfamily consisting of an INHBA homodimer.

Shalaeva et al. compare the structures of microbial rhodopsins (MRs) and G-protein coupled receptors (7TM hereafter) to propose a common functional mechanism centered on a conserved aromatic residue in TM helix 6.

Integration of existing genetic and biochemical data also supports an alternative mechanism centered on the movement of transcriptional factors between epidermal cells rather than a putative local activation of the WER gene function to determine root epidermis pattern formation (Savage et al., 2008).

These new approaches ultimately converged to reveal that the main property conferred by membrane-immersion is the ability to identify substrates through a mechanism centered on exposing intrinsic TM dynamics instead of the protein-protein binding strategy used by other specific proteases.

One area of investigation into cancer cell death mechanisms centers on the mechanism by which c-Myc stimulates or suppresses apoptosis.

Basic research in a variety of animal models has shown benefits of resveratrol including increased longevity, amelioration of cardiovascular disease, improved sensitivity to insulin, reduced aging-related neurocognitive decline and neuropathies, and reduced cataract formation through mechanisms largely centered on pathways ultimately related to Sirtuin gene activation [ 1- 3].