Sentence examples for mechanisms by targeting from inspiring English sources

Our second hypothesis was that drugs sharing the same therapeutic effect also share the same therapeutic mechanisms by targeting not only on the known target, but also on the same unexpected targets.

Pecot et al. demonstrated that miR-200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 that is secreted by tumor endothelial cells [ 58].

The plant extract may act through the inhibition of a particular enzyme, physiochemical mechanisms, by targeting the DNA/RNA or by targeting ion channels [ 35].

I-Smads act through diverse mechanisms: by targeting active receptor for proteasomal degradation [ 6, 7], inducing receptor dephosphorylation [ 8] and competing with R-Smad for the receptor binding site [ 9].

Curcumin induces cell death through a variety of mechanisms by targeting pathways acting through a range of transcription factors, membrane receptors, kinases, and cytokines (reviewed by Anand et al. [ 14]).

Pecot et al. demonstrated that miR-200 members inhibit angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 secreted from the tumor epithelial and cancer cells.

It is highly likely that A2C9-1 suppresses tumor cell growth through a similar mechanism by targeting IFN-induced FGFR1.

In this study we examined the hypothesis that drugs that share the same therapeutic effect also share a common therapeutic mechanism by targeting not only known drug targets, but also by interacting unexpectedly on the same cryptic targets.

Here, we report that in both normal and IPF primary human lung fibroblasts, PPAR-γ ligands potently block myofibroblast differentiation via a PPAR-γ-independent mechanism by targeting the TGFβ-induced PI3K-Akt pathway involving FAK.

This supports the idea that autophagy can provide a secondary antiviral mechanism by targeting viral RSSs for degradation.

Whereas CD45 is generally considered as having a positive and essential role in T cell activation, SHP-1 acts as a negative feedback mechanism by targeting tyrosine-phosphorylated components associated with the early events of T cell signaling such as LAT [ 74], Lck [ 48], ZAP-70 and the ξ homodimer [ 75].