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Mathematical models of atherosclerosis pose a particular challenge in that they require the description of multiple physical (mechanical, biochemical, etc)., time-varying processes and mechanisms at multiple scales, i.e., from the physiological (i.e., blood hemodynamics) to nanoscale mechanisms in the arterial wall.
Bone is a hierarchical material that involves fracture mechanisms at multiple scales ranging from nano- to macroscale.
A cross-layer design enhances the performance of the application by jointly considering the mechanisms at multiple network layers.
Effectively designed hydrometeorological EWS, which are integrated with institutional mechanisms at multiple levels of governance, have the potential to both mitigate the impacts of and increase resilience to hydrometeorological induced flood and drought risks.
An anti-IL-1 based approach would be expected to have a beneficial effect upon atherogenic mechanisms at multiple levels.
Specifically, this cascaded activation of mechanisms at multiple levels in the structural makeup of IFs explains the remarkable behavior of IFs that renders them capable to withstanding extreme deformation and large loads.
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This is one of the possible mechanisms functioning at multiple length scales that make bone a well-designed tough natural material.
We examine broad-scale patterns in old-field succession and introduce a hierarchical conceptual model to incorporate potential mechanisms operating at multiple spatial scales.
Invasion by non-native species poses a threat to native plant communities through mechanisms operating at multiple scales.
Overall, these numerous regulatory mechanisms operating at multiple levels offer fine control of signalling via the TGF-β/activin signalling pathway necessary to maintain good health.
It is likely that similarly complex mechanisms, operating at multiple points in the ethylene signaling pathway, will be uncovered as we begin to explore how ethylene interacts with other plant developmental pathways in more detail.
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