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Elucidation of the ways in which various integrin activation mechanisms are coordinated will contribute to the challenging and exciting goal of understanding and modulating cell adhesion and migration in diverse physiological and pathological microenvironments.
The timing of rhoptry mRNA increase followed by decay in the G1 phase of new parasites is consistent with the timing of de novo synthesis of these proteins in the previous mitotic period, and suggests that transcriptional as well as post-transcriptional mechanisms are coordinated in the parasite cell cycle.
This deeper understanding of how virulence mechanisms are coordinated will have both biotechnological and biomedical implications.
Interestingly, both mechanisms are coordinated and cooperate to finally give access to nucleosomal DNA.
Further studies are necessary to elucidate how these two important regulatory mechanisms are coordinated during cellular differentiation and proliferation in development.
Peroxiredoxins, catalase, and glutathione peroxidase are all capable of eliminating H2O2 efficiently [ 25, 26], but exactly how these many mechanisms are coordinated is not fully understood - although a deeper understanding of the functions of specific ROS detoxification enzymes and their interactions with classical phosphorylation-based signal transduction systems is slowly emerging.
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Host defense mechanisms in epithelial cells are coordinated by a complex program of gene expression.
The molecular mechanisms regulating gene expression are coordinated at the genome level where the accessibility of DNA sequences is determined by the structure of chromatin.
Intracellular defence against pathogens and pests is locally and systematically promoted by mechanisms of incompatible interaction, which are coordinated by resistance (R) genes [ 1].
The landscape we generated should facilitate the understanding of specific gene regulatory phenomena, such as the mechanisms by which nucleosome positions are coordinated in vivo.
Although targeting different host cell types, the merozoite, ookinete, and sporozoite parasite forms invade and develop by employing conserved molecular mechanisms, the majority of which are coordinated by calcium (Billker et al., 2009).
Related(20)
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mechanisms are cooperated
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