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Although initially targeted for applications in regenerative medicine, a novel application of this technology has been to generate experimental model systems for studying biological mechanisms and testing the efficacy of potential therapies.
Detailed characterization of animal models is of great importance to determine how closely they replicate the human disease pathology and define their relevance for investigating pathological disease mechanisms and testing potential therapeutical approaches.
The development of mouse models of COPD exacerbation, in parallel with the existing human experimental model [ 7], will allow insight into disease mechanisms and testing of potential therapies.
There is considerable interest in creating animal models of NMO for investigation of disease pathogenesis mechanisms and testing therapeutics [ 20, 21].
We conclude that, despite very real differences between laboratory and clinical settings, laboratory results obtained by studying healthy individuals can be useful in examining mechanisms and testing treatments for patients with lung disease.
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Experimental animals provide valuable opportunities to establish aetiological mechanisms and test new treatments for neurodevelopmental psychiatric conditions.
Scenarios are generated based on various network designs, information recommendation allocations and incentive mechanisms and tested regarding efficiency, stability and equity criteria.
The software that was used to create the new mechanisms and test the effects of roaming on combustion properties are freely available, with detailed tutorials that will enable it to be applied to fuels other than heptane and butanol.
Adipue and colleagues recently discovered that mice in their breeding colony spontaneously developed inflamed joints reminiscent of RA and may, therefore, have found a new model to examine pathogenic mechanisms and test new treatments for this human inflammatory disease.
Understanding the mechanism and testing it on the real virus, not just surrogates, he says, would be "the ultimate proof".
The fractured specimens were healed per the close-then-heal mechanism and tested again to fracture.
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