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The aging process involves multiple physiological mechanisms and represents one of the main risk factors for several human pathologies, such as cancer, diabetes, and cardiovascular disease.
Inbred rat strains and genetically segregating crosses are important tools in functionally proving disease mechanisms and represents a controlled setting where molecular interactions between different genetic factors as well as environmental factors can be tested [ 1].
In conclusion, SPCU is caused by an abrupt IP3R-mediated Ca2+ release from sub-PM SR elements facilitated by Ca2+ influx through VGCCs and serves to augment intracellular Ca2+ mobilization via CICE (acting on muscarinic cationic channels) and via CICR (acting on RyRs) mechanisms, and represents the key element in the chain of the signalling events in cholinergic contraction.
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However, it is likely that olfactory-specific AfunOBP genes are directly involved in olfactory mechanisms and represent "true" OBPs.
Probiotics are known to exert protective influence in the human intestine through various mechanisms and represent promising applications in prophylaxis and therapy.
Thus, human astrocytes can mediate neuroprotection through glutathione-dependent and glutathione-independent mechanisms, and represent a therapeutic target for human disorders associated with neuronal oxidative stress.
Insertions are usually a hallmark of NHEJ mechanisms and represent "information scars" at the repair sites of double stranded breaks (DSB) [ Lieber, 2008; McVey and Lee, 2008].
These findings are clearly related to underlying physiologic mechanisms and represent predictions that must be made quantitatively by mechanistic models of sepsis [ 13].
Clinical trials of nutritional interventions offer opportunities to develop and evaluate the short- and long-term consequences of undernutrition, identify disease mechanisms, and represent the ultimate route to evidence-based policy.
In this context, it is significant that small-molecule enhancers of torsinA activity have been reported (in Disease Models & Mechanisms) and represent putative molecular leads for ALS therapeutic development.
Although it is a critical point in the mechanism and represents a primer, it is strictly part of the passive antioxidant capacity of a protein.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com