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Unfortunately, it is difficult to accurately predict compound LD50 using a single QSAR model, because the acute toxicity may involve complex mechanisms and multiple biochemical processes.
In addition, the same causal mechanism may have different outcomes in different contexts while different causal mechanisms and multiple causes for the same effect may be at play in the same context.
This finding will contribute to further investigation of molecular mechanisms and multiple functions of hRNaseA family in general.
Numerous studies have shown that the progressive renal fibrosis is mediated by the growth factors, cytokines, metabolic toxins and stress molecules via complex mechanisms and multiple pathways.
Environmental chemicals may affect thyroid homeostasis by a number of mechanisms, and multiple chemicals have been identified that interfere with thyroid function by each of the identified mechanisms.
Various pathophysiologic mechanisms and multiple disease pathways have been studied in AF; however common molecular mechanisms underlying the initial development of AF and transition from paroxysmal to persistent AF remain unclear.
Similar(52)
The polypropylene matrix was found to deform by a shear yielding mechanism and multiple crazing was not observed.
To reduce the communication burden of each channel, a distributed event-triggered mechanism and multiple quantization scheme are firstly proposed.
Hot electron injection mechanism and multiple exciton generation from GQD to ZnO were mainly responsible for the photoexcitation response in PSSC.
As carcinogens are increasingly recognized to affect multiple molecular mechanisms and thus multiple cellular pathways, insights into these mechanisms could inform new predictive approaches, such as predictive in vitro assays, and allow for the development of specific, mechanism-based human biomarkers.
The potential effects of missing data will be explored under various models for nonignorable missing data mechanisms, and through multiple imputation models under ignorable missing data assumptions [ 51].
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