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However, this framework is limited in its utility for exploring the influence of variations within populations or interventions, or about the mechanisms of action or causal pathways thought to mediate outcomes, other contextual factors that might similarly moderate outcomes, or how and when these mechanisms and elements interact.
The challenge is to determine which cells are responsible for particular biological activities, to identify the regulatory mechanisms and elements that control them, and to determine how pathology develops when those mechanisms go awry and cause disease.
We propose that a mixture of both tumour autonomous mechanisms and elements within the microenvironment conspire to determine the response to anti-angiogenic therapy within individual tumours.
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It makes use of this information to develop reliability demonstration test plan for the identified (critical) failure mechanisms and physical elements.
Several different linear and non-linear analyses are carried out, including standard response spectrum analyses, limit analyses with both pre-assigned failure mechanisms and Finite Elements (FE), pushover and non-linear dynamic analyses.
This uses the retroduction approach, whereby the observed outcomes are explained by looking into the mechanisms and context elements.
Realist evaluation typically starts from a preliminary middle range theory which draws on existing knowledge and theory to articulate the links between outcomes, mechanisms and context elements.
Large scale transcriptomic studies of important life trait characteristics, such as growth, maturation, environmental tolerance and disease resistance, can provide important knowledge concerning underlying molecular mechanisms and control elements, assisting in the development of welfare-centred and sustainable management strategies for aquaculture species, e.g. [ 19, 20].
The rate of wound healing and the ability to reject parasites could also be explained by the characteristics of inflammatory responses to SL. Inflammation is regarded as a two-edged sword since destructive alterations are closely associated with the subsequent reparation of damaged tissues and often involve the same or closely related molecular mechanisms and cellular elements.
To characterize regulatory mechanisms and cis-elements of genes with similar patterns of expression, we used a new version of a comparative genomics-based cis-element analysis tool to identify clusters of cis-elements with compositional similarity among multiple genes.
The key elements in the framework are: biophysical element, process and institutional element, behavioral choice element, enforcement mechanisms and an outcome element.
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