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Future research on this topic should focus on ways to increase external validity, identify underlying mechanisms and develop more sophisticated techniques to simulate lot conditions.
In this paper, a finite element model of the two and three layer TBC's is developed in the commercial code ANSYS to investigate the buckle and interface delamination mechanisms and develop a simplified parametric understanding of these mechanisms.
Therefore, we utilized a quantitative proteomics strategy that combined 8-plex isobaric tags for relative and absolute quantitation (iTRAQ) labeling and two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC/MS/MS) to identify molecular signatures, reveal mechanisms, and develop predictive markers of OG patients with 1p loss of heterozygosity (LOH).
Future opportunities to investigate the molecular mechanisms and develop novel therapies for AF are also discussed.
Preclinical animal models are crucial tools to dissect disease pathogenic mechanisms and develop new therapeutic strategies.
Establishing animal models to study molecular mechanisms and develop new therapeutic strategies are therefore major preclinical needs.
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Merging of nanotechnology and whole-liver bioengineering approaches could provide several unanswered questions of regenerative mechanisms and developing extracorporeal liver systems.
Mapping the rewired host-pathogen 'superorganism' interaction network – along with its structural details – is critical for in-depth understanding of pathogenic mechanisms and developing efficient therapeutics.
This novel demonstration of inducible headache like pain using a dietary headache trigger represents an important step for characterizing mechanisms and developing therapeutics.
If differentiated cells from patient-specific iPS cells can faithfully recapitulate the disease phenotype, iPS cell technology will contribute significantly to revealing disease mechanisms and developing drug screening systems for disease.
Sharing material and data on RDs is essential for identifying disease-causing genes, studying pathological mechanisms, and developing treatments.
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