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A 5-year phase-out is a gentle mechanism to shift more of the funding overall to new investigators.
In this way, stimulation of ARF6-mediated endosomal recycling may act as a compensatory mechanism to shift endosomal transport equilibrium in favor of recycling, in turn alleviating cholesterol accumulation in the LE/LY.
The hydrolysis of pyrophosphate is an efficient mechanism to shift the very unfavorable equilibrium of ATPS reaction to the site of the products.
Our novel data suggest that breast cancer cells may utilize this mechanism to shift PR transcriptional action toward target genes that drive cell proliferation and pro-survival pathways.
The authors suggest that this could be a mechanism to shift protection from changes in single base pairs in favor of protection from major damage to DNA [ 12].
Work in mammalian systems suggests that Ire1 can be activated independently of an accumulation of unfolded proteins in the ER lumen, perhaps by utilizing such a mechanism to shift the oligomerization activation threshold [ 32].
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Tumor growth and metastasis require neovascularization, therefore, tumors use various mechanisms to shift the balance to an angiogenic inductive environment.
Here we have used recent evidence to speculate that regenerating appendages utilize several mechanisms to shift glucose metabolism toward anabolic pathways.
A current working model suggests that endocrine feedback influences hypothalamic AMPK via a number of mechanisms designed to shift an organism from negative to neutral energy balance.
Additionally, a novel mechanism is introduced to shift the threshold power level for designing different logic gates and functions.
The thermal conversion mechanism allows one to shift the microbolometer response to THz range and the mature infrared technology including manufacturing process, and readout procedures provide a good technical foundation.
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