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Thus, integration of the ERK/RSK signaling pathway provides a mechanism to modulate NFATc4 transcription activity.
Overall, these findings suggest an additional cytochrome c-mediated mechanism to modulate apoptosome formation, shedding light onto the rigorous apoptotic regulation network.
Cerebral arteries are (i) insensitive to sTNFR1-Fc ligand stimulation and (ii) clearly utilize a canonical soluble TNF/TNF receptor (that is, forward signalling) mechanism to modulate myogenic reactivity3,4,19.
We identify common design principals that highlight how the spatial organization of signal transduction circuits can be used as a fundamental control mechanism to modulate system outputs in vivo.
Meanwhile, the interaction between atmospheric gravity waves (AGWs) and ionospheric plasma has long been considered as a plausible mechanism to modulate the ionosphere (Hines 1960).
Taken together, these results further highlight the importance of the tetramer formation in PKM2 activation and suggest that the regulation of PKM2 oligomerization may be a general mechanism to modulate PKM2 activity.
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These data demonstrate that B. pertussis utilizes several mechanisms to modulate HLA-DR expression.
Interestingly, Flt3L treatment did not drive IRF8 expression above controls (Supplementary Fig. 6d), suggesting Flt3L and GCSF act through different mechanisms to modulate cDC1 differentiation.
H. pylori is known to utilize specific molecular mechanisms to modulate host immune response and create a local micro-environment that aids its colonization5,11.
Thus, our results suggest that MSC display different mechanisms to modulate the functional profile of macrophages.
Rather, HN may evoke other unidentified mechanisms to modulate NEP expression.
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