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Based on studies of ascospore germination, it has been suggested that L. pulmonaria spores use some mechanism to inhibit germination the inhibition is lifted when the spores are grown in a synthetic growth medium containing an adsorbent like bovine serum albumin or α-cyclodextrin.
Since phosphorylated PTEN is inactive and inhibits the Akt pathway, we propose that Ku80 heterozygous progenitors develop a compensatory mechanism to inhibit Akt-mediated inhibition.
Now it appears that CNS neurons also have a built-in mechanism to inhibit axon growth.
"I guess that our tissues have some mechanism to inhibit the reprogramming process in differentiated cells, but to prove that we need further studies," Obokata says.
Interestingly, previous studies have revealed a critical requirement of iron in Wnt signaling, and iron chelation serves as an effective mechanism to inhibit Wnt signaling in humans (Song et al., 2011).
Why Rdx uses different mechanism to inhibit Ci activity depending on the Hh signal strength?
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To implement this rapid switch from apoptotic susceptibility to strict inhibition, mature neurons appear to engage multiple mechanisms to inhibit the pathway of apoptosis.
AIs act through two distinct mechanisms to inhibit the action of aromatase and thereby reduce estrogen production [9].
CHK is unique among these inhibitors because it employs both catalytic and non-catalytic mechanisms to inhibit SFKs.
The contribution of excitatory mechanisms to pain are appreciated, whereby mechanisms to inhibit neuronal excitation have often been therapeutic targets in pain models [42, 43].
Tumor cells have developed immune escape mechanisms to inhibit the innate immune responses in the tumor microenvironment (Gajewski et al., 2013; Spranger et al., 2013).
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