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On the other hand, our model for UBL docking to the proteasome suggests that it is possible that Ddi1 uses only a single mechanism to bind the proteasome (direct binding to the LRR1 domain of Rpn1), whereas, in line with published reports [ 17, 18], Rad23 and Dsk2 may use multiple mechanisms (including the binding site disrupted by the D517A mutation) and thus are more resistant to mutation.
This study investigates the incorporation of hyaluronan (HA) binding peptides into poly ethylene glycol) (PEG) hydrogels as a mechanism to bind and retain hyaluronan for applications in tissue engineering.
AT utilises an induced-fit mechanism to bind with high affinity to a pentasaccharide sequence found in about one-third of heparin chains.
CRISPRs were identified as an unusual sequence element containing a series of 29-nucleotide repeats separated with 32-nucleotide ''spacer'' sequences in Escherichia coli genome (Ishino et al. 1987; Wiedenheft et al. 2012), and function as RNA interference mechanism to bind and cleave target DNA.
Molecular modeling and dynamics simulation of DmTDO-heme-Trp suggest that like prokaryotic TDOs, DmTDO adopts an induced-fit mechanism to bind l-Trp; in particular, two conserved but flexible loops undergo conformational changes, converting the active site from an open conformation to a closed conformation.
DNA polymerase I enzymes employ a complex induced-fit mechanism to bind and select the complementary nucleotide during DNA synthesis.
Similar(52)
I knew Dan's cooking and his obsessions in general were mechanisms to bind his anxiety, attempts to bring order to an unruly mind.
It is conceivable that ciliate and human telomerase use similar mechanisms to bind and synthesize telomeric DNA because of the high degree of telomere sequence similarity (TTGGGG and TTAGGG, respectively).
We show that Pan3 uses at least three different mechanisms to bind RNA, explaining its contribution to mRNA deadenylation.
Viruses such as dengue virus, vaccinia virus, and HIV-1 have evolved different mechanisms to bind host RRM-containing proteins to facilitate their genomes replication or mRNA translation [ 56– 58].
Although an interaction between the PAM2 motif of Pan3 and PABP/Pab1 can mediate indirect recruitment of Pan2 Pan3 to the polyA tail (Siddiqui et al, 2007), our data demonstrate that Pan3 can function through at least two additional complementary mechanisms to bind RNA directly.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com