Sentence examples for mechanism that implicates from inspiring English sources

Together, these studies suggest that ERK5 down-regulates Bim expression in neurons by a mechanism that implicates PKB-dependent phosphorylation of Foxo3.

The main finding of this study is that the guanidine compounds creatine and PCr can afford neuroprotection in an in vitro model of PD by a mechanism that implicates modulation of oxidative stress through the activation of the PI3K/Akt/GSK3β intracellular pathway.

In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NF κB, which could explain the presence of more severe forms of liver involvement in obesity-related NAFLD in the presence of OSAHS [ 11].

Furthermore, proinflammatory cytokines as IL-6, IL-1, and TNF- α will also contribute to the "vicious circle" of steatosis and inflammation by increasing the lipid deposits through a mechanism that implicates TLRs and leads to insulin resistance [ 49, 105, 112, 113].

In the presence of obesity, the proinflammatory state in these patients together with intermittent episodes of hypoxia, characteristic of OSAHS pathogenesis, may lead to an enhanced inflammatory response mediated by a positive feedback loop mechanism that implicates HIF-1 and NF κB.

Indeed, SOCE is the main mechanism that implicates Ca2+ import from extracellular to intracellular space, especially in nonexcitable cells [ 59].

Additional mechanisms that implicate p130Cas/BCAR1 in breast cancer invasion have been described.

Autophagy is an essential homeostatic cell response mechanism that is implicated in both types of cell death.

ADAM17 acts to shed EGF family ligands, a mechanism that is implicated in the development of mammary epithelium, heart valves, skin, and hair [17], [21], [22].

Threshold levels of MCP-1, MMP-2, or TGF-β1 activity trigger a feed-forward signaling mechanism that is implicated in the initiation and progression of adverse age-associated arterial wall remodeling.

Meanwhile, we found that PKC NF-κB contributed to the regulation of Nav1.8 exPKC NF-κBand contributedsito, anotheregulationng mechanism that was implicated in Nav1.8 mofulatioNav1.8