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This study was designed to determine the mechanism of thyroid hyperactivity after trifluralin exposure.
In summary, the mechanism of thyroid hypoplasia remains open and is different to what is decribed during pancreas development.
Identification of thyroid cancer-related genes and chemicals is helpful to understand the mechanism of thyroid cancer.
Similar associations have been described in HIV infections [ 121], however Beltran et al. could not find evidence for an autoimmune mechanism of thyroid disease in HIV patients [ 122].
The exact mechanism of thyroid disruption by PBDEs in humans has not yet been elucidated, but two potential pathways through which PBDE exposure could lead to thyroid disruption have been proposed [reviewed by Zhang et al. (2008)].
In order to get more insight about the molecular mechanism of thyroid cancer progression, we have here characterized, in normal and tumoral human thyrocytes and tissues, the expression of TACC3 gene which encodes for a protein substrate of Aurora-A.
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Kuiper, G. G., Kester, M. H., Peeters, R. P. & Visser, T. J. Biochemical mechanisms of thyroid hormone deiodination.
Gain-of-function mutations in oncogenes have aided our understanding of the molecular mechanisms of thyroid carcinogenesis.
While many of the mechanisms of thyroid toxicity of these substances are potentially complementary, little is known of the degree of interaction of common persistent contaminants on responses of the HPT axis.
However, there have been few reports concerning the effects of DBP and MBP on metamorphosis of X. laevis and the molecular mechanisms of thyroid system disruption.
The presently described culture system may be useful for regenerative medicine, but the primary importance will be as a tool to elucidate the mechanisms of thyroid diseases.
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