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Although the precise molecular mechanism of the dysfunction of these proteins remains unclear, an emerging model is that mutations or deletions impair neuronal circuitry by disrupting the formation, plasticity and maturation of glutamatergic synapses.
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The primary mechanism of this dysfunction in ovarian cancer is a missense mutation in the evolutionary conserved domains of the gene.
However, the exact mechanism of this dysfunction of intracellular ion transport remains unsettled.
The proposed mechanism of the iECs dysfunction induced by glucose toxicity are similar to the effects of pathological stimuli such as oxidative stress.
However, the treatment of acute he modynamic impairment should be tailored based on the etiological mechanism of the cardiovascular dysfunction.
Increased negative feedback of active cortisol on the HPA axis induced during inflammation may thus be the mechanism of dysfunction of the HPA axis in chronic inflammation.
Although the underlying mechanisms of the endothelial dysfunction in diabetes are complex and largely unknown, this dysfunction consistently occurs in both type-1 and type-2 diabetic patients7,8.
The mechanism of AD dysfunction might underlie the common features, while the regional feature would be the biomarker for the specific diseased tissues.
The mechanism of neurological dysfunction in the vascular system is tissue ischaemia, which produces varied clinical effects, with transient or prolonged symptoms.
However, little is known about the underlying mechanism of the male reproductive dysfunction and their side effects.
The nature and mechanisms of the brain dysfunction underlying pathophysiology of migraine are yet incompletely understood, but abnormalities of neuronal cortical excitability are believed to play an important role [1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com