Hollow, porous-particles added to HFA MDIs provide a mechanism for stabilizing suspensions of inhaled drugs, leading to improved physical stability, ability to formulate very low doses, consistent dose-to-dose performance, and high fine-particle fraction (FPF) [ 4, 5].
These findings support the hypothesis of a mechanism for stabilizing the active wakefulness state during L4int, resulting in the observed distribution of epoch durations.
However, most efforts have been focused on developing a stand-alone entity for each self-organizing mechanism, which will run in parallel with other entities, as well as designing coordination mechanisms in charge of stabilizing the network as a whole.
It was previously shown that many neighboring genes in head-to-head clusters showed correlated expressions across various conditions; however, most of the co-expressions were modest; instead, head-to-head clustering is a major mechanism for stabilizing transcription of genes in fundamental cellular processes rather than for co-regulating the two genes (Woo and Li, 2011; Russell et al., 2013).
Each of these mechanisms implies relaxation of stabilizing selection, resulting in faster evolution in paralogs than in single-copy genes.
While our analysis implies a possible human specific and dsRNA-mediated mechanism for stabilizing the expression of svPINK1, it also points to a broader genomic strategy for regulating a human disease locus and increases the complexity through which alterations in the regulation of the PINK1 locus could occur.
Given an ancestral Tm gene, Tn could have evolved after the cooperative mechanism as a means of stabilizing the blocking position of Tm.
Having a high level of PP2A B55δ could be a fail-safe mechanism for stabilizing the arrested oocyte.
This indicated that the incumbents' underlying strategic premises had remained unchallenged because of stabilizing mechanisms (Bingham and Kahl 2014; Schreyögg and Kliesch-Eberl 2007; Tripsas 2009).
