Sentence examples for mechanism of silencing from inspiring English sources

However, a recent study demonstrated DNA hypermethylation as a key mechanism of silencing CPS1 gene expression in human HCC.

Thus it is possible that the spatial production of small RNAs by MtDCL3 coincides with the spatial expression of MtAGO4b and MtAGO4c since they are related with the same mechanism of silencing.

Conceptually, being able to determine whether Rap1 occupies its binding site at HML and whether Abf1 occupies its binding site at HMR (McBroom and Sadowski 1995) would provide useful information regarding the mechanism of silencing.

Present results, however, seem to indicate a mechanism of silencing distinct from promoter methylation, as suggested by the underexpression of pivotal genes that function as transcriptional repressors in DNA methylation (EZH1) [ 35], histone modification (MLL4) [ 36], or chromatin remodeling (SMARCA4) [ 37].

These RNAi screens have much wider applications, since similar screens can now be adapted to identify the mechanism of silencing of any human disease-associated gene that is epigenetically regulated.

Therefore the mechanism of silencing remained unclear.

Lustig, A.J. Mechanisms of silencing in Saccharomyces cerevisiae.

Cell growth and mRNA profiles following expressed antisense RNA silencing differed somewhat from those following antisense PNA silencing, possibly reflecting different mechanisms of silencing.

In the eight remaining IDC specimens that lack DSC3 expression we predict that other mechanisms of silencing such as mutation to p53 or loss of other transcription factors are participating in DSC3 gene silencing.

Hypermethylation is described as possible mechanism of miRNA silencing.

Hypermethylation of gene promoters is a frequent mechanism of miRNA silencing at the transcriptional level [7].