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Our results reveal the mechanism of selectivity and activation for H4R, which is important for developing selective antagonists and agonists for H4R.
Despite all the advances in micro/nanotechnology, the fundamental mechanism of selectivity in sensing has not yet changed.
With the great success of crystallographic studies on ion channels, the potassium channels soon became a good prototype for comprehending the mechanism of selectivity for the various ions.
High selectivity of cyclic-nucleotide binding (CNB) domains for cAMP and cGMP are required for segregating signaling pathways; however, the mechanism of selectivity remains unclear.
Our data revealed not only interactions between genes that illustrate useful pathways for new therapeutic targets but also for understanding the mechanism of selectivity of CDV.
Importantly, Pentobra has an additional mechanism of selectivity not available to tobramycin: Pentobra has preferential activity against bacterial membranes compared to mammalian membranes, because it selectively permeates membranes enriched in negative spontaneous curvature lipids like those with PE headgroups.
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The map encompasses intermolecular recognition and mechanisms of selectivity comprised by patterns of selective interactions and specific structural properties.
In order to identify the structural mechanisms of selectivity, we developed a peptide-docking algorithm to predict the atomic structure of protease-substrate complexes and applied it to a large and diverse set of cleavable and noncleavable peptides.
Although the detailed or underlying mechanisms of selectivity of Phyllanthus plant against skin and prostate cancer cells is still unclear, our findings have revealed that Phyllanthus plant exerts its growth inhibition towards cancer cells through modulation of cell cycle and induction of apoptosis via caspases activation.
Understanding the mechanism of this selectivity will enable better polymeric vectors to be designed, with inherent selectivity for specific cell types based on intracellular differences and not on the use of targeting ligands, which have shown variable success, depending on the system.
However, the mechanism of its selectivity towards α3β2, α6/α3β2β3, and α3β4 nAChRs remains elusive.
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mechanism of specificity
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