Sentence examples for mechanism of pathogenicity from inspiring English sources

In most cases, when one missense variant is known to be pathogenic, a different nucleotide change that results in the same amino acid [ e.g. c.34G>C (p.Vand2Leu) and c.34G>T (p.Val12Leu)] can also be assumed to be pathogenic, particularly if the mechanism of pathogenicity is through altered protein function.

When classifying such variants as pathogenic, one must ensure that null variants are a known mechanism of pathogenicity consistent with the established inheritance pattern for the disease.

However, one must exercise caution in classifying these variants as pathogenic by considering the following principles: When classifying such variants as pathogenic, one must ensure that null variants are a known mechanism of pathogenicity consistent with the established inheritance pattern for the disease.

They are associated with specific bacteria which are also involved in the mechanism of pathogenicity and which are consumed by nematodes as living food.

We also investigated another possible mechanism of pathogenicity by using hybridization-based capture and next-generation sequencing of the homologous chromosome for ten 16p13.11-deletion patients to look for unmasked recessive mutations.

The causal relationship of XMRV infection to human disease and the mechanism of pathogenicity have not been established.

This neglect is unfortunate, because comparing the vertebrate pathogens with related species can help to elucidate the mechanisms of pathogenicity, transmission and virulence [ 26, 27].

Shigella flexneri and EIEC are pathogenic microorganisms known to cause disease in humans by very similar mechanisms of pathogenicity.

Currently, the disease is effectively controlled by planting resistant hybrids [ 4], but the pathogen remains an important subject of investigation as a model for mechanisms of pathogenicity and virulence as well as the evolutionary processes generating highly virulent strains.

The selection of suitable GMO candidate strains can be made under in vitro conditions using basic knowledge on molecular mechanisms of pathogenicity of the corresponding bacterial species rather than by in vivo testing of large numbers of random mutants.

This study elucidates the genetic basis of the unique pathogenicity of M. abscessus among RGM, and raises the question of similar mechanisms of pathogenicity shared by unrelated organisms in CF patients.