However, to understand the molecular mechanisms of mechanosensing and subsequent reinforcement of the mechanical coupling of the adhesion complex, further information on the response of other molecules of the adhesion complex to mechanical load will be needed.
Convective forces are present whenever a hydrated tissue undergoes dynamic mechanical strain, and so convection could not only dominate the transport of large molecules like proteins, but might also serve as a mechanism for mechanosensing.
We believe that this will lead to a comprehensive view of podosome collective behaviour and deepen our knowledge about the significance of mechanosensing mediated by protrusive structures.
The PA scaffolds developed in the present study can be used for further investigation into the mechanism of MSC mechanosensing in the 3D context.
Taken together, it is likely that the Yonemura model in which α-catenin is the force-activated molecule at the Cadherin complex applies to FAJs in junction formation, but it is clear that several key details are missing to fully understand the mechanism of Cadherin mechanosensing.
It provides a general physical molecular mechanism for mechanosensing of cells at the adhesions to sense and adapt to their microenvironments.
The specific sensory mechanisms available in plants for detecting sound are still unclear although they are likely to be an aspect of the multifaceted phenomenon of mechanosensing, the intrinsic ability to sense and respond to mechanical perturbations, which all organisms exhibit in order to grow and develop.
One hypothesis of mechanosensing in bone states that osteocytes can sense the flow of fluid through the canalicular system.
Changes in the expression of SSTR can be involved in alterations of chemical sensitivity as well as of mechanosensing in afferent mesenteric nerves [62].
