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Parmeggiani, F. et al. Mechanism of inflammation in age-related macular degeneration.
Allen, K., Jaeschke, H. & Copple, B. L. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.
The arthritis of leprosy deserves wider recognition and study as it contributes to disability and may hold clues to the mechanism of inflammation in other rheumatic disorders.
Several of the body's routine processes, including cell metabolism and the defence mechanism of inflammation, produce "oxygen radicals" - atoms of oxygen with an extra unpaired electron that make them particularly eager to react with other molecules in ways that can create all kinds of health problems, including cancer.
As a consequence, when the control mechanism of inflammation does not function properly and the inflammation persists, diseases including cancer may develop [7, 8].
Costly research into the mechanism of inflammation led to Cox-2 inhibitors for arthritis, including Merck's Vioxx and Pharmacia 's Celebrex.
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In order to study neutrophil-mediated formation of carcinogenic N-nitroso compounds as a mechanism of inflammation-related colon carcinogenesis, we designed an in vitro model for intestinal inflammation, consisting of a coincubation system with human colon cells (Caco-2 cells) and activated human neutrophils (PMN), as important immunoreactive cells.
One important mechanism of inflammation-induced cancer is due to oxidative stress [8] [11], which results from the release of free radicals from activated immune cells and cytokines.
Above were the examples of mechanism of inflammation-related tumor invasive characteristics.
We demonstrate here that ER stress leads to hepatic NLRP3 inflammasome pyroptotic death, thus contributing as a novel mechanism of inflammation-mediated liver injury in chronic liver diseases.
In the eye, a stepwise mechanism of inflammation-associated de novo lymphangiogenesis involves potential lymphatic progenitor cells [ 49] derived from circulation that transmigrate through the connective tissue stroma, presumably in the form of macrophages [ 49- 51], and finally incorporate into the growing lymphatic vessels [ 52].
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