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Therefore, it is useful to carry out 1D and 2D NMR experiments simultaneously in order to reveal the mechanism of complex molecular motions.
These studies revealed a dynamic mechanism of complex formation that involves large conformational changes in the GRK5 RH/catalytic domain interface upon receptor binding.
Our results highlight the power of the TCF analysis to elucidate the molecular mechanism of complex allosteric processes in large biomolecular systems.
We attribute these enhancements in transfection efficiency to the differences in the mechanism of complex formation by the different variants of the parent peptide which in turn are related to the chemical nature of the peptide itself.
The main objective of this work was to investigate for the first time the molecular mechanism of complex formation between bromelain (a positively charged enzyme) and carrageenan (a natural strong polyelectrolyte, negatively charged) using spectroscopy techniques and thermodynamic approaches.
Here, we address the mechanism of complex formation using a combination of protein engineering, pre-steady-state kinetics and isothermal titration calorimetry, in order to understand the underlying basis for specificity.
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The above theoretical results should be very useful in the analysis of DNA-binding mechanism of complexes and the designs of binding agents to DNA, etc.
It is an attractive alternative to visualizing the underlying mechanisms of complex molecular phenomena.
Data and findings from these and many other projects help researchers to elucidate mechanisms of complex biological processes such as diseases and aging.
The kinetics and mechanisms of complex L L PTC processes are not properly understood.
Mark A. Johnson, the Arthur T. Kemp Professor of Chemistry, has sought to expand the role of contemporary physical chemistry, addressing mechanisms of complex synthetic pathways at the molecular level.
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