Sentence examples for mechanism is defective from inspiring English sources
"If you know the gene and the function of the gene, then you know which biological mechanism is defective," Meyre told CNN.
One interesting question concerns the fault tolerance of protein interaction networks: whether there exist alternative pathways that can perform some required function if a gene essential to the main mechanism is defective, absent or suppressed.
57 The hypoglycemia counterregulartory mechanism is defective in older people.
If the centrosome orientation mechanism is defective, a high frequency of centrosome misorientation would result, although this scenario does not necessarily lead to spindle misorientation.
We propose that phosphorylation of NBR1 by GSK3 modulates the formation of protein aggregates and that this regulation mechanism is defective in a human muscle proteinopathy.
The negative correlation that we have found between the levels of memory T cells and Treg expansion by the combination of TGFβ and RA in SLE patients suggests that at least the latter mechanism is defective, either because there are too many memory T cells or they are refractory to RA inhibition.
Cessna's lawyers argued that the seat did not slip and denied the locking mechanism was defective.
In fact careful electrophysiological measurements on GK rat beta cells strongly indicate that the events downstream of glucose metabolism in the canonical GSIS mechanism are defective [37].
Indeed, major clinical signs of emotional disturbance (eg, anhedonia) suggest that some emotional mechanisms are defective in patients with schizophrenia.
The three mechanisms were defective natriuresis leading to sodium and fluid retention, exacerbation of diastolic dysfunction from increased blood pressure and damage of pulmonary capillary blood-gas barrier from increased intracapillary pressure and release of neurohumoral mediators, such as angiotensin II, catecholamines and endothelin-1.
Since IL-10 is not essential for all Treg-dependent functions, this leaves open the question of the precise nature of the suppressive mechanism that is defective in p110δD910A Tregs.
