Again, this indicates that the parental tumor harbored multiple resistance mechanisms in distinct subclones.
We also found that phenotypically identical pain syndromes are induced through different molecular mechanisms in distinct sets of sensory and sympathetic neurons.
Although the identity of the fibroblast sheddase remains to be determined, these results highlight that shedding of a cell surface protein may occur by very different mechanisms in distinct cell types.
By comparing s.c. B16 tumor growth in syngeneic C57BL/6J mice, allogeneic FVB/NJ mice, semi-syngeneic C57 × FVB F1 mice, fully chimeric C57/FVB mice and C57/FVB chimeric mice devoid of C57 skin, a complex interplay of local immune tolerance and defense mechanisms in distinct tumor rejection is suggested.
Epigenetic machinery is involved in the establishment of this pattern, and manipulation of its mechanism results in distinct patterns of var gene expression.
This triad was initially identified in trypsin-like serine proteases and later found in the other distinct folds such as subtilisins, serine carboxypeptidases and Clp proteases, though the catalytic residues occur in a different order in their sequences: a typical example of convergent evolution of the same biochemical mechanism in structurally distinct folds [ 6, 33, 34].
Quantitative changes in the avoidance response could be due to either a single molecular mechanism proportionately changing with intensity of the stimulus, or multiple separate molecular mechanisms operating in distinct temperature ranges, which converge onto a qualitatively similar avoidance response.
Here, we show that these two silencing mechanisms result in distinct chromatin structures.
Our data strongly suggest the existence of pVHL-independent mechanisms, resulting in distinct gene expression outputs which reflect common biologic pathways in renal cell cancer.
Potentially unexplored exceptions to the well-known mechanism may exist in distinct genome locations and cell systems.
