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Analysis of the effects of residue substitution with respect to other superfamily members provides a mechanism for the identification of conserved catalytic strategies and characterization of structure/function relationships responsible for differences in reactivity, substrate selectivity, and regulation.
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The Perform Achieve Trade programme has introduced mechanisms for the identification of industry sector, designated customer, specific energy consumption and target setting.
Knowledge of genetic regulators of neurodegeneration is important not only for an understanding of potential neuroprotective mechanisms but for the identification of potential new drug targets.
These first studies clearly underline the potential value of patient-specific hiPSC-derived cardiomyocytes for a deeper understanding of disease mechanisms and for the identification of novel drug targets.
As part of future research, these results may become a mechanism-driven foundation for the identification of natural compounds potentiating cancer therapeutic efficacy or cancer chemoprevention.
In this context host-pathogen systems biology can provide highly relevant clues, not only for the elucidation how the pathogen captures the host signalling mechanisms, but also for the identification of novel targets for therapeutic interventions.
It resulted that only GTP decreases the formation of the GBP1 PIM1 complex through an allosteric mechanism, putting the bases for the identification of new compounds potentially able to revert resistance to paclitaxel.
Our goal in the present study was to obtain a profile of the genes modulated by bexarotene on mammary gland from three transgenic mouse mammary cancer models in an effort to elucidate its molecular mechanism of action and for the identification of biomarkers of effectiveness.
Contracts can provide a useful mechanism for the identification, tracking, and validation of security vulnerabilities.
Knowledge of components of the cytoskeleton is necessary to understand the invasion mechanisms as well as for the identification of possible therapeutic targets.
The expectation is that molecular technologies will provide novel insights into disease mechanisms and thus allow for the identification of more accurate diagnostic, prognostic, and theranostic (i.e., predicting response to targeted treatment) biomarkers.
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