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Purinergic receptor activation by local nucleotide release might constitute an autocrine and/or paracrine mechanism for modulation of biliary secretion.
Taken together, these findings suggest a mechanism for modulation of NMDA receptor activity through the control of translational efficiency of a single subunit.
A major mechanism for modulation is alternative RNA splicing resulting in N-CAM's with different cytoplasmic domains that differentially interact with the cell membrane.
These data suggest that integrin ligation and FAK activation synergize with wnt signaling through a Grb2-rac-jnk-c-jun pathway, providing a context-dependent mechanism for modulation of wnt signaling.
These data identify a unique mechanism for modulation of TSC2 repression of mTOR signaling via membrane retention of this tumor suppressor, and identify PC-1 as a regulator of this downstream component of the PI3K signaling cascade.
As to the molecular mechanism for modulation, we reasoned that in the protonated form, R224 prevents occupancy of the selectivity filter by K+, thus creating a blocked state, a situation relieved by neutralization of R224 at alkaline pH [20], [22].
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Apart from LTP, there are other mechanisms for modulation of memory.
However, the number of risk alleles identified with plausible mechanisms for modulation of gene expression is outweighed by SNPs falling in gene desert regions [ 11].
Future studies should determine the etiologies and strategies for management of joint pain, including fibromyalgia, in patients with chronic HCV and HIV infection, as well as the mechanisms for modulation of joint symptoms in HIV/HCV-coinfected patients.
Based on the plethora of fundamental and epidemiological studies carried out, it is possible to specify two fundamental mechanisms for modulation of cancer risk by polymorphisms of genes encoding PRRs and proteins of PRR pathways.
Furthermore, genes involved in acetylation and methylation processes were also downregulated as direct consequence of TEL-AML1 induction with binding of TEL-AML1 fusion protein to the respective promoter regions, stressing the importance of epigenetic mechanisms for modulation of transcription factor activity.
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