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The transplanted MSCs might, as a principal mechanism, export their inherent trophic effect to unorthodox sites [44].
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The Sec secretion pathway can also utilize a co-translational mechanism of export that couples translation of proteins by the ribosome with secretion through the SecYEG channel [the signal peptide recognition particle (SRP) pathway].
Clearly the secretion of vesicularized Zn pools would provide a successful mechanism to export the large amount of Zn into milk that is required by the developing neonate.
It has been suggested that T6SS may use a unique but unknown mechanism to export its proteins, which probably cross the bacterial cell membrane in a single step [24].
Therefore, SNAVI provides a mechanism to export the biggest component in a network into a new sig file for analysis.
Surprisingly, mRNA uses a Kap- and Ran-independent mechanism for export (Santos-Rosa et al. 1998; Katahira et al. 1999).
The mechanism of export and uptake of HSPs between immunogenic tumor cells with immature DCs remains to be elucidated.
The reviewers raise a series of interesting questions on the relationship between the diffusion-based mechanisms of intra-Golgi traffic and the mechanism of export from the Golgi.
p53 mis-localization arising from an aberrant import mechanism, hyperactive export, or sequestration with a cytoplasmic factor has been observed in several cancers.
However the latter theory is not supported by the finding of higher activity of AP in NS than in serum unless a mechanism to export the AP against a concentration gradient is present in this tissue.
Regarding secreted molecules, our group has recently discovered that leishmania use a non-classical secretion mechanism to export a majority of their secreted proteins, which involves the release of small vesicles called exosomes [ 6, 7].
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