Sentence examples for mechanism disruption from inspiring English sources

Given this proposed contribution of TNR hairpins to the expansion mechanism, disruption of such structures via strand invasion offers a potential means to negate the disease-initiating expansion.

Indications for revision were aseptic loosening of a hinged prosthesis (8 knees), loosening and bone loss associated with chronic extensor mechanism disruption (2 knees), component instability with chronic medial collateral ligament disruption (3 knees), and comminuted distal femur fracture (1 knee).

Whatever the mechanism, disruption of Rev trafficking and therefore HIV-1 mRNA export function represents a major antiviral activity of Nullbasic.

There is relevant documentary evidence to support that fractures that are displaced more than 8 mm are likely to be accompanied by disruption of the extensor mechanism, and some patients may be able to perform a straight leg raise, even in the presence of an extensor mechanism disruption, due to an intact iliotibial band and medial or lateral patellar retinaculum.

The molecular circadian clock regulates the temporal pattern of transcription and we believe that by this mechanism, disruptions in the molecular clock could also disrupt consolidation of memory.

Role and contribution of various possible mechanisms (disruption of "central", "peripheral" tolerances, T cell anergy, etc).

We have previously shown that chemicals capable of inducing MN by strictly similar mechanisms (disruption of microtubule polymerisation) act together according to the principles of CA (Ermler et al. 2013).

Therefore, a cascade of abnormal events is induced during cervical carcinogenesis, including the induction of genomic instability, reprogramming of cellular metabolic pathways, deregulation of cell proliferation, inhibition of apoptotic mechanisms, disruption of cell cycle control mechanisms, and alteration of gene expression.

Beyond its conventional role as a negative feedback regulator of TGF-β/BMP signaling, Smad6 negatively regulates Toll-like receptor (TLR) 4 signal through dual mechanisms: disruption of the Pellino-1-mediated TLR4 signaling complex (Choi et al, 2006) and selective degradation of MyD88 (Lee et al, 2011).

Soluble oligomers of amyloid proteins are able to permeabilize cellular membranes and lipid bilayers and disrupt membrane functions; the mechanism of disruption is not clearly understood.

Disruption of CCR5 signaling in the tumor slows tumor growth through a Treg-mediated mechanism, although disruption of the CCL5/CCR5 axis skews migration of only about 20% of the CD4+ population (less Tregs, more Teffs).