Interestingly, when these neurons are ablated in the newborn period the effects on body weight and food intake are much more modest, suggesting that network-based compensatory mechanisms can develop in neonates but do not readily occur in adults.
By elucidating these mechanisms, we can develop strategies to induce this tolerance in other strains, such as industrially used strains.
Polyploid cells – those with more than two sets of chromosomes – are normally eliminated by cell-autonomous mechanisms; when this mechanism fails, cancer can develop.
With a better understanding of the immunologic mechanisms, we now can develop better treatment approaches and design further research in intervention of allergic eye diseases.
As the cellular mechanisms unfold, one can develop effective targeted therapy to eradicate the EBV latency.
These results show that dysregulation of PMS2 gene expression can disrupt MMR function in mammalian cells and establish an additional carcinogenic mechanism by which cells can develop genetic instability and acquire resistance to cytotoxic cancer therapies.
Gibson et al. showed that dysregulation of PMS2 gene expression can disrupt MMR function in mammalian cells and establish an additional carcinogenic mechanism by which cells can develop genetic instability and acquire resistance to cytotoxic cancer therapies [ 31].
Isaac Megbolugbe, vice president for research at the Fannie Mae Foundation, said the study was commissioned, in part, because the foundation wanted "to have a way of anticipating the impact of these kinds of investments so we can develop mechanisms to capture some of their value and address the problem of gentrification" prompted by the programs' success.
In addition to the mechanisms described above, hematomas can develop in relation to anticoagulant therapy, Henoch-Schonlein purpura, and blood dyscrasias.
As a result of MMP activity tumor cells can develop mechanisms to evade immune responses, resulting in promotion of tumor survival, acquisition of metastatic phenotype and further tumor dissemination [10].
