These features make targeting a single pathway insufficient, as cancers use redundant carcinogenetic mechanisms and shift from one signaling pathway or hallmark to another.
--Trends in the business practices of local Palestinian businessmen, such as changes in enterprise ownership and control mechanisms and shifts in contract bidding methods.
It funds solutions to problems that are too big for current funding mechanisms, and shifts risk from the government to the private sector, allowing government to innovate in ways it cannot today.
At the gene transcript level, the overall fungal response to the bacteria was similar for both S4 and AS13 and large-scale changes in the fungal transcriptome were evident suggesting the simultaneous alteration of primary metabolism, activation of defence and attack mechanisms and shifts in hyphal morphology and growth.
It ends with a plea for careful research design and sample selection, construction of causal mechanisms, and a shift toward comparative and statistical rather than single-case analyses.
Other alterations to the stock Protegé interior include more suede-like trim on the doors, and both a tighter gearbox and shift mechanism from aftermarket parts maker Sparco, and Sparco's sporty metal pedals.
Sprangers and Schwartz [ 1] added reprioritization of values as a third aspect of response shift phenomena and proposed a theoretical model, revised and updated here, to clarify and predict changes over time in perceived QOL as a result of the interaction of catalysts, antecedents, mechanisms, and response shifts.
Influenza A virus has the ability to undergo changes by the mechanisms of antigenic drift and shift, resulting in new evolving virus strains, which may be extremely toxic and drug-resistant [3] [5].
Each opa gene undergoes phase variation via a frame shift mechanism, and therefore, a single gonococcus can express no Opa proteins, one Opa protein, or multiple Opa proteins simultaneously [17], [18].
The balance between the Chapman mechanism and the smog mechanisms shifted towards the smog mechanism as one moved towards cooler stars.
