Sentence examples for mechanism activation of from inspiring English sources

However, unlike the case for the mono-zinc mechanism, activation of Thr285 by proton transfer to Asp465 resulted in a significant structural change in the active site that involves dissociation of this residue from the Zn1 metal ion.

We considered one mechanism: activation of the hypothalamic pituitary adrenal (HPA) axis [ 41 48].

Perhaps by this mechanism, activation of NF- κB can protect leukemic cells from apoptotic killing (Jeremias et al, 1998).

These studies help to understand the mechanism activation of catB which might help in designing new catB inhibitors.

In addition to the central mechanism, activation of mitochondria by the cytokines in the peripheral tissues may also contribute to the energy expenditure.

In their proposed mechanism, activation of RaC1 induces cortical actin fiber rearrangement and intensification of the junctional VE-cadherin, resulting in reduced permeability.

Thus PKD2 can regulate myogenic differentiation by affecting two transcriptional mechanisms, activation of Mef2D and inhibition of Pax3 transcriptional activity.

Among the EGFR downstream signalling mechanisms, activation of the MAPK cascade has special relevance in the regulation of inflammatory events.

Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT).

The mechanism of protection probably involves multiple effects including metabolic effects, antioxidant mechanisms, activation of KATP channels, as well as inhibition of inflammatory cell activation.

This issue will give insight into cellular and molecular mechanisms, activation of signaling pathways, how activation of these pathways causes muscle dysfunction, and subsequent disease symptoms.