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How do art, design, mechanics, and cell biology inspire bioengineering?
Actin networks play a key role in cell mechanics and cell motility.
Wang, H., Cai, L., Paul, A., Enejder, A. & Heilshorn, S. C. Hybrid elastin-like polypeptide polyethylene glycol (ELP-PEG) hydrogels with improved transparency and independent control of matrix mechanics and cell ligand density.
Our study shows the impact of heparin intercalation at specific binding sites in telopeptide-free collagen fibrils in terms of their structure, mechanics, and cell response.
The complexity of the inner cell composition and the intricate meshwork formed by transmembrane cell-substrate interactions demands a non-invasive technique to probe cell mechanics and cell adhesion at a subcell scale.
Gundiah studies tissue mechanics and cell mechanobiology.
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However, little is known about the contribution of matrix mechanics and cell-generated forces to stable cell-cell contact and tissue formation.
My laboratory works on the interface of mechanics, physics, and cell biology, seeks to understand how physical properties and biological function affect each other in cellular systems, and how physical and material laws govern the behavior of living cells and their abilities to deform, move, remodel, and function.
For tissue engineering scaffolds and controlled cell culture applications, degradation affects the hydrogel crosslink density and mechanics and hence cell behavior, where ideally the rate of degradation should match the rate of new tissue formation.
The plasma membrane and the actomyosin cortex control surface mechanics and determine cell surface tension.
The objective of this study was to prepare and determine the structure, mechanics, and the cell response in vitro and in vivo of ECM hydrogels prepared from decellularized porcine dermis and urinary bladder tissues.
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