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For clinical trials in which blinding is not feasible at the point of intervention (potential methodologic issue for mechanical ventilation trials), high quality can still be assigned if the investigator collecting the primary outcome is blinded to the treatment allocation.
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The increase of Ht is a risk factor and has adequate discriminative capacity and calibration to predict failure in weaning from IMV. Key words: Failure of weaning from mechanical ventilation, spontaneous breathing trial, haematocrit.
As we were unwilling to require the use of mechanical ventilation for the trial, we included only patients who needed mechanical ventilation for any medical reason after CSE.
Also, MH reduced duration of mechanical ventilation in that trial.
University of Pittsburgh Department of Critical Care Medicine Strom T, Martinussen T, Toft P: A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomized trial.
For example, in the ARDSNet trials involving critically ill patients receiving mechanical ventilation (Low Tidal Volume Trial and the Fluids and Catheter Treatment Trial), approximately 1% of research subjects were deemed competent to provide their own consent.
APACHE, Acute Physiology and Chronic Health Evaluation; CFU, colony-forming units; CHX, chlorhexidine; CPIS, clinical pulmonary infection score; I/C, intervention/control; ICU, intensive care unit; MV, mechanical ventilation; RCT, randomized controlled trial; VAP, ventilator-associated pneumonia.
The following search terms, alone or in combination, were used: stress ulcer, histamine-2-receptor antagonists, ranitidine, cimetidine, famotidine, sucralfate, mechanical ventilation, and randomized controlled trials.
With the increase in life expectation, more admissions to hospital, use of mechanical ventilation (MV) and weaning trials in older patients have been observed.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedeto midine for Long-Term Sedation Investigators: Dexmedetomidine vesus midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
In spite of its early termination this study presented certain methodological advantages over previous trials: mechanical ventilation and fluid administration were controlled in both groups, and the control group received a less proinflammatory diet, as well as a high intake of proteins, which may have had a beneficial effect.
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