In univariate analysis, ESBL acquisition was associated with male gender, SAPS II, SOFA, chronic kidney disease at admission, duration of mechanical ventilation, need for catecholamine and the ICU LOS.
These factors comprised infrastructural (hospital size, academic affiliation, leading medical discipline, implemented treatment protocols) or patient-associated (leading diagnosis, severity of illness, mechanical ventilation, need of catecholamine or vasopressor support) aspects.
Risk factors associated with mortality were SAPS-2, scorescore, neurological and/or respiratory failure on admission, alveolar haemorrhage, time between onset of symptoms and antibiotherapy, need for invasive mechanical ventilation, need for vasoactive support, kaliemia, pH, lactate, base excess, bilirubinemia and blood products transfusion.
Thirty-day major cardiac events defined as death, cardiac arrest, mechanical ventilation, need for catecholamine and thrombolysis, will be evaluated as a secondary end point.
Complications during the exacerbation were recorded (i.e., hemoptysis, pneumothorax, respiratory insufficiency, need for noninvasive mechanical ventilation, need for invasive mechanical ventilation, and death).
We found a certain relation between mechanical ventilation need and radiological findings, but the assumed ongoing real practice is important and the value of radiologic evaluation beyond clinical findings to predict the mechanical ventilation need is subject for further evaluation with large patient series.
Results: Patients who developed ICU complications (fever, sepsis, pneumonia, required mechanical ventilation, needed vasopressors or blood transfusion); showed higher ΔMPV compared to non complicated cases (Fig. 2).
As medical students we were told that mechanical ventilation needs convective gas flow.
In only two (5%) patients were endotracheal intubation and mechanical ventilation needed.
Persistence of high levels of lactate, total amount of organic failures, shock, mechanical ventilation needs and previous renal disease were related to mortality in older people diagnosed with severe sepsis and septic shock.
Thus, there is a sound rationale that predicting readiness of patients to be successfully liberated from mechanical ventilation needs to be based on objective weaning predictors that can be applied in clinical decision making.
