Mechanical ventilation (MV) comprises two major functions.
For patients who required mechanical ventilation, who comprised half of the cohort, ICU survival was 62% and 47% were alive at hospital discharge [ 1].
Thus, 150 patients were analyzed (41 ± 26 years, BMI 26 ± 6, SAPS II 46 ± 18, Ramsay score = 5 or 6: 83%, mechanical ventilation 99%), comprising 79 patients with circulatory failure (MAP 70 ± 12 mmHg, norepinephrine (n = 62) 0.3 ± 0.3 μg/kg/minute, epinephrine (n = 2) 0.15 ± 0.14 μg/kg/minute).
In the USA, Wunsch et al 2 projected that 3% of inpatient hospitalisations required mechanical ventilation in 2005, comprising 30% of all ICU admissions and accounting for a disproportionate 12% of all hospital costs.
Supportive treatment in the Neonatal Intensive Care Unit (NICU) comprises mechanical ventilation, cardiovascular support, and treatment of infections and seizures [ 6].
The management of ARDS comprises mechanical ventilation with low tidal volume (VT), a plateau pressure (Pplat) <30 cm/H2O, and positive end-expiratory pressure (PEEP) adjusted to the fraction of inspired oxygen (FiO2) [ 3].
Mechanical ventilation and weaning comprise one of the most common treatment options to sustain lung function in critically ill patients.
Mechanical ventilation could be required.
Mechanical ventilation may trigger an inflammatory response, comprising alveolar macrophage activation and recruitment, which may be specifically, repeatedly and spatially assessed by functional imaging techniques such as Positron Emission Tomography combined with Computerized Tomography (PET/CT) [2].
Our sample frame comprised all ICUs providing mechanical ventilation to critically ill adults in Denmark, Norway, Switzerland, the UK, and the Netherlands identified through existing intensive care networks.
