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In animals, mechanical ventilation at high volumes and high pressures can cause ventilator-induced lung injury (VILI) with similar histological appearance to ALI/ARDS.
Exclusion criteria were mechanical ventilation at admission.
Removal of PEEP and continuation of mechanical ventilation at ZEEP.
48 patients required mechanical ventilation at the inclusion.
mechanical ventilation at high settings (FiO2 > 0.9, P-plat > 30) for ≥ 7 days.
Clinical and laboratory data, namely the reason of mechanical ventilation at ICU admission, were recorded.
Consequently CNS impairment with concomitant respiratory disease was the biggest indication for mechanical ventilation at 29.67%.
Mechanical Ventilation at high tidal volumes and pressures induces in lung oedema which is undistinguishable from ARDS.
The end-expiratory occlusion (EEO) test consists in interrupting mechanical ventilation at the end of expiration during 15 seconds.
Patients with mechanical ventilation at the intensive care unit have failed extubation in 5 to 25% of the cases.
Figure 1 Macroscopic aspect of rat lungs after mechanical ventilation at 45 cm H 2 O peak airway pressure.
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