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The YES2 SpaceMail mission has been planned as a low-cost international effort to provide a facility for the return of small samples from the ISS back to Earth, based on an inflatable re-entry capsule and a mechanical tether system.
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From the mechanical standpoint, myosins can convert chemical energy by ATP hydrolysis into mechanical energy to power intracellular transportation or mechanical tethers.
Epidural fibrosis may extend into the neural canal and adhere to the dura mater and nerve roots, with mechanical tethering of nerve roots or dura by adhesions, which may in turn contribute to persistent back and leg pain following lumbar laminectomy.
However, a regulated short-range motor protein-based system may be advantageous, as it provides a mechanism tethering organelles at actin-rich intracellular sites and/or exerting mechanical forces [11].
For mTNF to transduce a mechanical signal, it must tether to another membrane-bound protein: TNF receptors are obvious tethering partners.
Local LOX activity could be stimulated by higher mechanical load imposed by tethering to the infarct or signals could diffuse from the scar.
The mechanical properties can be tethered by choosing the appropriate pore size and porosity and designing the dimension of the cylinder-shaped skeletons.
It is equally possible that these tethers provide mechanical integrity without coupling to transduction channels, analogous to lateral links in hair bundles.
Thus, unlike the majority of nociceptors, cutaneous mechanoreceptors require a distinct protein tether to transduce mechanical stimuli.
For example, the molecular tension based fluorescence microscopy (MTFM) approach uses polyethylene glycol (PEG) as a force-sensitive tether molecule to measure mechanical tension across growth factor 66 and cell adhesion receptors 31, 41 (Fig. 2e).
The NPCs, which are distributed throughout the NE and in the membrane of the tethers may directly influence the mechanical properties of the membrane and may account for the slight bulge seen at the tip of the tether by electron microscopy but not in the model (Fig. 4).
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