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The mechanical tension provided by an altered ECM is likely to act on HCC development and progression via outside-in signalling, for example by integrins, (discussed below) to support tumour growth and progression.
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Still, the finding that autophagy is necessary for maintaining the architecture of the actin cytoskeleton under mechanical tension provides a novel conceptual framework for our understanding of these pathologies.
These results uncover an essential mediator of Hippo signaling by cytoskeleton tension, providing a new entry point to dissecting how mechanical signals regulate Hippo signaling in living tissues.
Whatever the pathologic mechanism, it implies an acute mechanical tension exerted by the PLT.
Based on these findings, we speculated that the fragmented collagen had lost its ability to provide structural support for the imbedded cells and that this resulted in a loss of mechanical tension on the cells.
The network of collagen tissue is maintained by its mechanical tension with these skin cells.
T 0 and T are the initial and induced mechanical tension in the nanowire, respectively.
Failure due to mechanical tension, however, could stretch the material, producing significant scarring and preventing complete self-healing, he suspects.
To better manage mechanical tension, we propose a modified mesh design with extensions and demonstrate its mechanical superiority.
Electromyographic (EMG) amplitude and mechanical tension are directly related during isometric contraction.
One such fibrogenic stimulus may be mechanical tension.
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