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Exposing heart fibroblasts to constant versus cyclic mechanical stretch resulted in differences in collagen gene expression [ 98].
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Our data supports that ischemia stimulates cytokine expression via TLR4-independent mechanisms (such as mechanical stretch), resulting in similar myocardial levels of TNF and IL-1β in both strains.
Most importantly, mechanical stretches resulted in upregulation of these proteins (Fig 2B).
The incorporation of rest periods in a mechanical stretching regimen results in greater collagen type I synthesis.
Mechanical ventilation, while life-saving, can cause additional lung damage due to repetitive cyclic mechanical stretch of the lung resulting in increased inflammation and lung tissue injury this is termed "ventilator induced lung injury" (VILI) [2].
Stimulation of bladder afferent neurons by mechanical stretch of chemical irritation results in voiding responses that may be voluntary or involuntary in nature [ 2].
It has been demonstrated that ventilator-induced mechanical stretch may also lead to the destabilization of alveolar-epithelial and capillary-endothelial barriers thereby resulting in increased vascular permeability and pulmonary edema [4]-[6].
In general, application of mechanical stretch, fluid flow, and compression results in increased expression of extracellular matrix components.
Mechanical stretch of the portal vein results in an early activation of the MAPK/ERK pathway and smooth muscle growth.,, This is followed by a delayed activation of the Rho/Rho-kinase/cofilin pathway, which promotes actin polymerization.
Recent reports also showed that mechanical stretch on cultured podocytes stimulated Ang II production, resulting in a reduction of nephrin expression, but not podocyte apoptosis.
As we reported previously, cyclic (0.25 Hz) mechanical stretch to 37% ΔSA for 60 minutes in our control groups resulted in significant increases in untreated monolayer permeability [4].
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