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Based on these reports and data generated by our cross-species analysis of ALI, we speculated that mechanical stretch causes the initial injury to the pulmonary endothelium, which is followed by platelet aggregation at the damaged site and activation of the coagulation cascade.
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Chapter I (The role of PDGF signalling in (patho)- physiologic lung development) emphasizes the importance of PDGF-Rα expressing myofibroblasts (MFBs) in alveolarization that is hindered by mechanical ventilation and stretch causing abrogation in the receptor leading to reduced migration and disrupted elastin deposition.
Mechanical ventilation, while life-saving, can cause additional lung damage due to repetitive cyclic mechanical stretch of the lung resulting in increased inflammation and lung tissue injury this is termed "ventilator induced lung injury" (VILI) [2].
This "mechanical stretch" is no longer the exclusive, big-deal domain of expensive suiting by Jil Sander or Calvin Klein.
Application of cyclic mechanical stretch improved contractile function, cardiomyocyte alignment along the stretch axis and gene expression of cardiomyocyte markers.
Differential proteins under mechanical stretch are also profiled, especially for those events undetectable in transcriptomic analysis.
In this study, we have shown that mechanical stretch triggers the NF-κB signaling pathway.
Fig. 2 HCA attenuates alveolar epithelial injury following 24 and 120 h of cyclic mechanical stretch.
How mechanical stretch influences CKIs is unknown.
Alternatively, changes in beating calcium may activate hypertrophy through mechanical stretch pathways.
Mechanical stretch induced MIP-2 in rat lung cells [ 6].
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