To further enhance pre-osteoblast cell differentiation as well as improving mechanical strength, bone-like apatite particles (<2 μm) were incorporated onto the surface of NF-gelatin scaffolds via a simulated body fluid (SBF) incubation process.
Interestingly, this ratio is close to the optimal ratio of thickness/radius =0.07 from calculations of mechanical strength in tube-like bones [ 4].
The cylinder-shaped PLLA sponge prepared with 150 250 μm NaCl particulates showed the highest mechanical strength, suggesting that a cylinder-like PLLA sponge with pores ranging between 150 and 250 μm in size was architecturally stronger and more appropriate for applications in tissue engineering when high mechanical strength is necessary than the other tested configurations.
You can also impart other properties, like mechanical strength.
Despite the increasing rates observed in the use of polymers, ceramics, and composites, metals are still the most important engineering materials to achieve excellent properties like mechanical strength and corrosion resistance.
"The problem starts right at the very early stage, where there was a requirement that dwelt mainly on the accuracy of the weapon, rather than anything else, like mechanical strength or reliability," says an officer involved in trials in the 80s.
Increasingly, SF is exploited in other areas of biomedical science, as a result of new knowledge of its processing and properties like mechanical strength, elasticity, biocompatibility, and controllable biodegradability [ 15].
However, its poor mechanical strength under complex stress and powder-like appearance hinder its application.
Combination of PLLA/PLGA sponges with fibrin matrices provided added mechanical strength and featured highly mature vessels-like networks.
The outer porous coating should exhibit bone-like architecture, high mechanical strength and good bioactivity to bond to bone, whereas the interlayer should be chemically stable in biological fluids to avoid detachment between the joined parts.
