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Cardiomyocytes in the body are subjected to cyclic mechanical strain induced by the rhythmic heart beating.
Thus, mechanical strain induced in ternary compound under high-energy influence is responsible to the evolution of MCT surface morphology as well as stipulates peculiarity of the mass and charge transport in this material.
Mechanical strain induced in MCT ternary compound under high-energy influence is responsible to the evolution of surface morphology as well as stipulates peculiarity of the mass and charge transport in this material.
It was interesting that whereas mechanical strain induced TGFβ activation, ET-1 and CCN2 and TGFβ mRNAs, but not type I collagen or αSMA mRNAs, were induced.
Thus, stretch-activated calcium channels may especially contribute to the local [Ca2+]i increase due to the mechanical strain induced by the EF, and cause a depolarization-activated calcium response [30] at the rear-end (cathode) of the SaOS-2 cell.
Our study here pointed out that mechanical strain induced much more ROS in adult MSCs, which is at least one of the main causes of the deficient osteogenic differentiation potential of adult MSCs as ROS blocker NAC partially rescues the defect.
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The next goal is to elucidate the mechanism by which mechanical strain induces latent TGFβ activation, since doing so could help us to fully understand how we could treat and ultimately prevent tendon disease.
The physical mechanism of this coupling is as follows: the mechanical strain induces changes in the domain patterns and polarization distribution; this in turn changes the local electric fields sufficiently that space charges are redistributed on the free surface rather than moving towards the bottom electrode.
Collectively, these data suggest that mechanical strain induces CCN2 expression and cell proliferation via its ability to cause activation of latent TGFβ by a cell contraction (actin/myosin and FAK/src -dependent mechanism.
Mechanical strain induces ECM breakdown [ 5].
We and others have previously shown that mechanical strain induces proliferation of osteoblast-like cells [82,83].
More suggestions(15)
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mechanical anisotropy induced
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