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This is particularly true if a mechanical stimulus affects, both, cells that have regained excitability (these may depolarize, giving rise to ectopic foci, thus providing a trigger for arrhythmogenesis), and cells at more positive membrane potentials (whose repolarization time-course is altered, potentially furnishing an arrhythmia-sustaining substrate).
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A body of cues is known about how these mechanical stimuli affect cell morphology, proliferation, and differentiation.
While conceptually similar to the vulnerable window for electrical stimulation, there is a principally relevant difference in that mechanical stimuli affect cardiac tissue in a localized fashion.
The growing number of evidence has demonstrated the role of both biochemical and biomechanical signals in regulating MSC lineage-specific differentiation, where mechanical stimuli affect the metabolism of bone cells and their precursors.
Also the timing of the mechanical stimuli could affect our results.
However, whether mechanical stimulus can also affect Na+cyt loads that should be inherently linked to Ca2+cyt changes has not been determined yet.
Although the mechanisms underlying postprandial fullness remain unclear, we speculate that some mechanical or chemical stimuli affecting intestinal wall (duodenum and/or small intestine) may play critical roles in causing the sensation of postprandial fullness.
For example, mechanical loading, applied macroscopically, is transferred to the mechanosensitive osteocytes (residing in the lacunar pores), which then transduce the respective mechanical stimulus into biochemical responses affecting osteoblasts and osteoclasts in the vascular pores.
In detail, postsynaptic density protein 95 (PSD-95) binding with GluN2B subunit modestly affects the mechanical stimulus as a mechanical clutch through regulating cytoskeletal destabilization [ 136].
In the cultures, growth cone-driven elongation is likely not affected, but the mechanical stimulus required to sustain interstitial growth is missing.
Also, the sensory response to a mechanical stimulus is non linear and can be affected by adaptation and fatigue.
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